K+ channel subfamily K member 4; TWIK-related arachidonic acid-stimulated K+ channel protein; TRAAK; two pore K+ channel KT4.1 (KCNK4, TRAAK)

Function

• voltage insensitive, instantaneous, outwardly rectifying K+ channel
• outward rectification is reversed at high external K+ concentrations (putative)

Structure

• homodimer (putative)
• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

membrane (potential)

Alternative splicing

named isoforms=2

Notes

• at lease one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• K+ channel subfamily K
• glycoprotein
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NYG8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50801
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:50801
• OMIM: https://mirror.omim.org/entry/605720