K+ channel subfamily K member 1; Inward rectifying K+ channel protein TWIK-1; K+ channel KCNO1 (KCNK1, HOHO1, KCNO1 TWIK1)

Function

• weak inwardly-rectifying K+ channel
• activated by protein kinase C

Structure

• homodimer (putative)
• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

membrane (potential)

Expression

• widely expressed
• high levels in heart & brain
• lower levels in placenta, lung, liver & kidney

Notes

• inhibited by Ba+2, quinine, quinidine & internal acidification

More general terms

• K+ channel subfamily K
• phosphoprotein
• glycoprotein
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3775
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3775
• OMIM: https://mirror.omim.org/entry/601745
• UniProt: http://www.uniprot.org/uniprot/O00180.html