solute carrier family 6 member 14 (SLC6A14, Na+ & Cl- dependent neutral & basic amino acid transporter B0+, amino acid transporter ATB0+)

Function

• mediates uptake of a broad range of neutral & cationic amino acids (except proline) (Na+/Cl- dependent)
• transport inhibited by BCH (2-aminobicyclo-[2.2.1]-heptane-2-carboxylic acid)

Structure

• belongs to the Na+:neurotransmitter symporter (SNF) family

Compartment

membrane

Expression

• expressed in adult & fetal lung, in trachea & salivary gland > mammary gland, stomach & pituitary gland > colon, uterus, prostate & testis

Pathology

• genetic variations in SLC6A14 may be associated with susceptibility to X-linked obesity

More general terms

• solute carrier family 6

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1125
• OMIM: https://mirror.omim.org/entry/300306
• OMIM: https://mirror.omim.org/entry/300444
• UniProt: http://www.uniprot.org/uniprot/Q9UN76.html