high affinity cationic amino acid transporter 1; CAT-1; CAT1; system Y+ basic amino acid transporter; solute carrier family 7 member 1; ecotropic retroviral leukemia receptor homolog; ecotropic retrovirus receptor homolog; ERR (SLC7A1, ATRC1, ERR, REC1L)

Function

• high-affinity, low capacity permease
• in transport of cationic amino acids (arginine, lysine & ornithine) in non-hepatic tissues
• may also function as ecotropic retroviral leukemia receptor

Structure

• belongs to the amino acid-polyamine-organocation (APC) superfamily, cationic amino acid transporter (CAT) (TC 2.A.3.3) family

Compartment

membrane

Expression

ubiquitous

More general terms

• transmembrane 14 protein
• amino acid transport protein
• solute carrier family 7 (SLC7, SLC7A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6541
• OMIM: https://mirror.omim.org/entry/104615
• UniProt: http://www.uniprot.org/uniprot/P30825.html