cystatin M (cystatin-E, cystatin-6, CST6)

Function

• moderate inhibition of cathepsin B
• not active against cathepsin C
• substrate for transglutaminases
• acts as an acyl acceptor but not as an acyl donor

Structure

belongs to the cystatin family

Compartment

secreted

Expression

• restricted to the stratum granulosum of normal skin & the secretory coils of eccrine sweat glands
• low expression levels are found in the nasal cavity

Pathology

• restricted to the stratum granulosum/spinosum of psoriatic skin

More general terms

• cystatin

Database

• UniProt: http://www.uniprot.org/uniprot/Q15828.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1474
• OMIM: https://mirror.omim.org/entry/601891
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1474