glia-derived nexin; GDN; peptidase inhibitor 7; PI-7; protease nexin 1; PN-1; Serpin E2 (SERPINE2, PI7, PN1)

Function

• serine protease inhibitor
• activity toward thrombin, trypsin, & urokinase
• promotes neurite extension by inhibiting thrombin
• binds heparin

Structure

belongs to the serpin family

Compartment

secreted, extracellular space

Alternative splicing

named isoforms=2

More general terms

• protease nexin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5270
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5270
• OMIM: https://mirror.omim.org/entry/177010
• UniProt: http://www.uniprot.org/uniprot/P07093.html