glutathione peroxidase-1 (GSH-Px1, cellular glutathione peroxidase, GPX1)

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Function

2 glutathione + H2O2 <--> glutathione disulfide + 2 H2O

Structure

Compartment

cytoplasm

Expression

Pathology

Pharmacology

More general terms

References

  1. UniProt http://www.uniprot.org/uniprot/P07203.html
  2. 2.0 2.1 Journal Watch 23(24):191, 2003 Blankenberg S, N Engl J Med 349:1605, 2003 pmid: https://www.ncbi.nlm.nih.gov/pubmed/14573732
  3. UniProt http://www.uniprot.org/uniprot/P07203.html
  4. Wikipedia, Glutathione peroxidase entry http://en.wikipedia.org/wiki/Glutathione_peroxidase
  5. Kil J, Lobarinas E, Spankovich C et al Safety and efficacy of ebselen for the prevention of noise- induced hearing loss: a randomised, double-blind, placebo- controlled, phase 2 trial. Lancet. July 14, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28716314 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31791-9/fulltext
    Maison SF, Rauch SD Ethical considerations in noise-induced hearing loss research. Lancet. July 14, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28716312 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31875-5/fulltext

Database