glutathione peroxidase-1 (GSH-Px1, cellular glutathione peroxidase, GPX1)
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Function
- protects hemoglobin in erythrocytes from oxidative breakdown
2 glutathione + H2O2 <--> glutathione disulfide + 2 H2O
Structure
- homotetramer
- belongs to the glutathione peroxidase family
Compartment
Expression
- highly expressed in auditory hair cells
Pathology
- higher blood levels associated with lower rates of cardiovascular events in patients with suspected coronary artery disease[2], relative risk 0.29 from highest vs lowest quartiles
Pharmacology
- ebselen mimics activity of GPx1 & may prevent noise-induced hearing loss
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P07203.html
- ↑ 2.0 2.1 Journal Watch 23(24):191, 2003 Blankenberg S, N Engl J Med 349:1605, 2003 pmid: https://www.ncbi.nlm.nih.gov/pubmed/14573732
- ↑ UniProt http://www.uniprot.org/uniprot/P07203.html
- ↑ Wikipedia, Glutathione peroxidase entry http://en.wikipedia.org/wiki/Glutathione_peroxidase
- ↑ Kil J, Lobarinas E, Spankovich C et al Safety and efficacy of ebselen for the prevention of noise- induced hearing loss: a randomised, double-blind, placebo- controlled, phase 2 trial. Lancet. July 14, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28716314 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31791-9/fulltext
Maison SF, Rauch SD Ethical considerations in noise-induced hearing loss research. Lancet. July 14, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28716312 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31875-5/fulltext