NADPH-dehydrogenase [quinone] 2; ribosyldihydronicotinamide dehydrogenase [quinone] NRH dehydrogenase [quinone] 2; quinone reductase 2; QR2; NRH:quinone oxidoreductase 2 (NQO2, NMOR2)

Function

• quinone reductase in connection with conjugation reactions of hydroquinones
• role in detoxification pathways
• role in biosynthetic processes including vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin (putative)
• uses dihydronicotinamide riboside (NRH) rather than NADH/NADPH as an electron donor

1-(beta-D-ribofuranosyl)-1,4- dihydronicotinamide + quinone
              <-->
1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone

Cofactor:

• binds 1 Zn+2 ion per subunit
• FAD

Kinetic parameters:

• KM=28 uM for NRH
• KM=11.6 uM for menadione
• KM=252 uM for NADH

Structure

• homodimer
• belongs to the NADH/NADPH dehydrogenase (quinone) family

Compartment

cytoplasm

More general terms

• diaphorase
• quinone reductase

Database

• UniProt: http://www.uniprot.org/uniprot/P16083.html
• OMIM: https://mirror.omim.org/entry/160998