cytochrome P450 26A2 (CYP26A2, CYP26B1, retinoic acid-metabolizing cytochrome, cytochrome p450 subfamily 26A polypeptide 2)

Function

• retinoic acid metabolism
• inactivation of all-trans-retinoic acid
• catalyzes 4-hydroxylation & 18-hydroxylation of retinoic acid resulting in:
  • 4-hydroxyretinoic acid
  • 4-oxo-retinoic acid
  • 18-hydroxyretinoic acid
• preferred activity: all-trans-retinoic acid > 9-cis-retinoic acid > 13-cis-retinoic acid

Compartment

membrane-bound, endoplasmic reticulum

Expression

• highly expressed in brain, particularly cerebellum & pons
• induced by retinoic acid

More general terms

• cytochrome P450

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5660
• OMIM: https://mirror.omim.org/entry/605207
• UniProt: http://www.uniprot.org/uniprot/Q9NR63.html