cytochrome P450 8B1 (CYP8B1, sterol 12-alpha-hydroxylase, 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase)

Function

• involved in bile acid synthesis
• catalyzes conversion of 7-alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one
• determines balance between formation of cholic acid & chenodeoxycholic acid
• broad substrate specificity including 7-alpha-hydroxylated C27 steroids

Compartment

endoplasmic reticulum membrane

Expression

expressed in liver

More general terms

• cytochrome P450

Database

• OMIM: https://mirror.omim.org/entry/602172
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1582
• UniProt: http://www.uniprot.org/uniprot/Q9UNU6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1582