cytochrome P450 2J2 (arachidonic acid epoxygenase, CYP2J2)

Function

• metabolizes arachidonic acid via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosa- trienoic acids
• epoxidation of endogenous cardiac arachidonic acid pools

Structure

belongs to the cytochrome P450 family

Compartment

membrane-bound, endoplasmic reticulum

Expression

• expressed in heart > liver, ileum, jejunum, colon, kidney

More general terms

• cytochrome P450

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1573
• OMIM: https://mirror.omim.org/entry/601258
• UniProt: http://www.uniprot.org/uniprot/P51589.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1573