alkyldihydroxyacetonephosphate synthase, peroxisomal; alkyl-DHAP synthase; aging-associated gene 5 protein; alkylglycerone-phosphate synthase (AGPS)

Function

• glycerolipid metabolism; ether lipid biosynthesis
• may be part of an heterotrimeric complex composed of DAP-AT, ADAP-S & a modified form of DAP-AT

Cofactor: FAD

Structure

• belongs to the FAD-binding oxidoreductase/transferase type 4 family
• contains 1 FAD-binding PCMH-type domain

Compartment

• peroxisome membrane
• localized to the inner aspect of the peroxisomal membrane

Pathology

• defects in AGPS are the cause of rhizomelic chondrodysplasia punctata type 3

More general terms

• transferase
• phosphoprotein

Additional terms

• peroxisome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8540
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8540
• OMIM: https://mirror.omim.org/entry/600121
• OMIM: https://mirror.omim.org/entry/603051
• UniProt: http://www.uniprot.org/uniprot/O00116.html