dihydroxyacetone phosphate acyltransferase; DAP-AT; DHAP-AT; acyl-CoA:dihydroxyacetonephosphateacyltransferase; glycerone-phosphate O-acyltransferase (GNPAT, DAPAT, DHAPAT)

Function

• membrane lipid metabolism; glycerophospholipid metabolism
• may be part of an heterotrimeric complex composed of DAP-AT, ADAP-S & a modified form of DAP-AT

acyl-CoA + glycerone phosphate = CoA + acyl-glycerone phosphate

Structure

• the HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
• belongs to the GPAT/DAPAT family

Compartment

• peroxisome membrane; matrix side
• exclusively localized to the lumenal side of the peroxisomal membrane (putative)

Pathology

• defects in GNPAT are the cause of rhizomelic chondrodysplasia punctata, type 2

Laboratory

• dihydroxyacetone phosphate acyltransferase in fibroblasts

More general terms

• acyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8443
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8443
• OMIM: https://mirror.omim.org/entry/222765
• OMIM: https://mirror.omim.org/entry/602744
• UniProt: http://www.uniprot.org/uniprot/O15228.html