GDP-L-fucose synthetase (protein FX, red cell NADPH-binding protein, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, tissue-specific transplantation antigen 3, TSTA3)

Function

• 2 step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase & a reductase reaction
• carbohydrate biosynthesis; GDP-L-fucose biosynthesis via de novo pathway GDP-L-fucose from GDP-D-mannose, step 2 [final step]

GDP-L-fucose + NADP+ <--> GDP-4-dehydro-6-deoxy-D-mannose + NADPH

Structure

• homodimer
• belongs to the fucose synthetase family

More general terms

• epimerase
• oxidoreductase

Database

• OMIM: https://mirror.omim.org/entry/137020
• UniProt: http://www.uniprot.org/uniprot/Q13630.html