thioredoxin-like protein 5; 14 kD thioredoxin-related protein; protein 42-9-9 (TXNL5, TRP14, TXNDC17)

Function

• disulfide reductase
• reversible oxidation of its active center dithiol to a disulfide
• dithiol-disulfide exchange reactions
• modulates TNF-alpha signaling & NF-kappa-B activation
• has peroxidase activity
• elimination of cellular hydrogen peroxide (putative)
• interacts with TRXR1 & DNCL1
  • oxidized protein is reduced by TRXR1

Structure

• belongs to the thioredoxin family
• contains 1 thioredoxin domain

Compartment

cytoplasm

Expression

ubiquitously expressed in cell lines

More general terms

• oxidoreductase
• thioredoxin-like protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BRA2.html