gamma-parvin (PARVG)
Jump to navigation
Jump to search
Function
- role in regulation of cell adhesion & cytoskeleton organization (putative)
- interacts with integrin-linked protein kinase & actin
Structure
- belongs to the parvin family
- contains 2 CH domains (calponin-homology domains)
Compartment
- cell junction, focal adhesion, cytoplasmic side
- constituent of focal adhesions
Alternative splicing
named isoforms=3
Expression
- expressed in lymphoid organs, including spleen, thymus, lymph node, bone marrow & peripheral blood leukocytes > digestive tract, including stomach, duodenum, jejunum, ileum, ileocecum & appendix = lung, liver
Pathology
- expressed in tumors, but at a lower level than in the corresponding normal tissues