kelch-like protein 3 (KLHL3 KIAA1129)

Function

• probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex that mediates ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• interacts with CUL3

Structure

• contains 1 BTB/POZ domain
• contains 6 kelch repeats

Compartment

• cytoplasm, cytoskeleton

Alternative splicing

named isoforms=3; A, B, C

Expression

• expressed in many tissues

More general terms

• kelch-like protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26249
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26249
• OMIM: https://mirror.omim.org/entry/605775
• UniProt: http://www.uniprot.org/uniprot/Q9UH77.html