Ankyrin repeat & KH domain-containing protein 1 (multiple ankyrin repeats single KH domain, HIV-1 Vpr-binding ankyrin repeat protein, hMASK, ANKHD1, KIAA1085, MASK, VBARP, PP2500)

Function

• may play a role as a scaffolding protein
• isoform 2 may possess an antiapoptotic effect & protect cells during normal cell survival through its regulation of caspases
• interacts with PTPN11
• isoform 2 interacts with VPR

Structure

• belongs to the mask family
• contains 25 ANK repeats
• contains 1 KH domain

Compartment

cytoplasm

Alternative splicing

named isoforms=5

Expression

• ubiquitous
• high expression in cervix, spleen & brain.
• expressed in hematopoietic cells
• isoform 2 is highly expressed in spleen with almost no expression in muscle & brain

Pathology

• increased expression in leukemia cells
• may be associated with the abnormal phenotype of leukemia cells

More general terms

• ankyrin repeat domain protein (ANKRD)
• scaffold protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8IWZ3.html