ankyrin repeat domain-containing protein 17 (gene trap ankyrin repeat protein, serologically defined breast cancer antigen NY-BR-16, ANKRD17, GTAR, KIAA0697)

Function

• earliest specific in situ marker of hepatic differentiation during embryogenesis
• useful for characterization of inductive events involved in hepatic specification

Structure

• contains 25 ANK repeats
• contains 1 KH domain

Compartment

• cytoplasm, nucleus
• detected around the nucleolus

Alternative splicing

named isoforms=5

Expression

expressed in bone marrow

Pathology

• target of enterovirus 71, major etiological agent hand, foot & mouth disease
• interacts with VP1 capsid protein of enterovirus 71 (EV71)

More general terms

• ankyrin repeat domain protein (ANKRD)

Database

• UniProt: http://www.uniprot.org/uniprot/O75179.html