wnt16 proto-oncogene protein; protein Wnt-16 (WNT16)

Function

• ligand for members of the frizzled family of serpentine receptors
• probable developmental protein
• may be a signaling molecule which affects the development of discrete regions of tissues
• likely to signal over only few cell diameters (putative)

Structure

belongs to the Wnt family

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

named isoforms=2; Wnt-16a; Wnt-16b

Expression

• isoform Wnt-16a is expressed at significant levels only in the pancreas
• isoform Wnt-16b is expressed in peripheral lymphoid organs including: spleen, appendix, & lymph nodes, in kidney but not in bone marrow

More general terms

• wnt proto-oncogene protein or int proto-oncogene protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51384
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51384
• OMIM: https://mirror.omim.org/entry/606267
• UniProt: http://www.uniprot.org/uniprot/Q9UBV4.html