Wnt-13 proto-oncogene protein protein Wnt-2b; (WNT2B, WNT13)

Function

• ligand for members of the frizzled family of serpentine receptors
• probable developmental protein
• may be a signaling molecule which affects the development of discrete regions of tissues
• likely to signal over only few cell diameters
• may be involved in normal development or differentiation

Structure

belongs to the Wnt family

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

named isoforms=2

Expression

• isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine & colon; in the adult brain, isoform 1 is found mainly in the caudate nucleus, subthalamic nucleus & thalamus
• also detected in fetal brain, lung & kidney
• isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis & cancer cell lines

Pathology

• may be involved in carcinogenesis

More general terms

• wnt proto-oncogene protein or int proto-oncogene protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7482
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7482
• OMIM: https://mirror.omim.org/entry/601968
• UniProt: http://www.uniprot.org/uniprot/Q93097.html