GTP-binding protein Rit2 (Ras-like protein expressed in neurons, Ras-like without CAAX protein 2, RIT2, RIN, ROC2)

Function

• binds & exchanges GTP & GDP (putative)
• rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members (putative)
• interacts with MLLT4, the C-terminal domain of RALGDS & RLF, but not with RIN1 & PIK3CA
• RLF binds exclusively to the active GTP-bound form (putative)
• binds calmodulin

Structure

belongs to the small GTPase superfamily, Ras family

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

neuron-specific

More general terms

• ras subfamily protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q99578.html