NF-kappa-B inhibitor-interacting Ras-like protein 2; I-kappa-B-interacting Ras-like protein 2; Kappa B-Ras protein 2; KappaB-Ras2 (NKIRAS2 KBRAS2)

Introduction

Atypical ras-like protein

Function

• regulates NF-kappa-B activity
• inhibits degradation of NFKBIB
• inhibits phosphorylation of NFKBIB (putative)
• inhibits nuclear localization of RELA NF-kappa-B subunit
• both GTP- & GDP-bound forms block phosphorylation of NFKBIB
• interacts with PEST domain in both NFKBIA & NFKBIB in vitro
• probably only interacts with NFKBIB in vivo

Structure

• unlike other ras family proteins, conserved Gly & Gln in positions 13 & 65 are replaced by Leu in KBRAS1 & KBRAS2
• KBRAS1 & KBRAS2 resemble constitutively active, oncogenic forms of Ras
• belongs to the small GTPase superfamily, Ras family, KappaB-Ras subfamily

Compartment

• cytoplasm

Alternative splicing

named isoforms=2

Expression

• widely expressed

More general terms

• ras subfamily protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=28511
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:28511
• OMIM: https://mirror.omim.org/entry/604497
• UniProt: http://www.uniprot.org/uniprot/Q9NYR9.html