CUG-BP-& ETR-3-like factor 5 (CELF-5, Bruno-like protein 5, RNA-binding protein BRUNOL-5, BRUNOL5, CELF5)
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Function
- RNA-binding protein
- role in regulation of pre-mRNA alternative splicing
- mediates exon inclusion &/or exclusion in pre-mRNA that are subject to tissue-specific & developmentally regulated alternative splicing
- specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition
- binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA
Structure
- belongs to the CELF/BRUNOL family
- contains 2 RRM (RNA recognition motif) domains
Compartment
Alternative splicing
named isoforms=2
Expression
expressed in brain, heart