polypeptide N-acetylgalactosaminyltransferase 6 (protein-UDP acetylgalactosaminyltransferase 6, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6, polypeptide GalNAc transferase 6, GalNAc-T6, pp-GaNTase 6, GALNT6)
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Function
- glycosylation
- catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, transfer of an N-acetyl-D-galactosamine residue to a Ser or Thr on the protein
- synthesis of oncofetal fibronectin (putative)
- activity toward Muc1a, Muc2, EA2 & fibronectin Cofactors: Mn+2, Ca+2
Compartment
Golgi membrane
Expression
- expressed in placenta, trachea > brain, pancreas
- expressed in fibroblasts