protein sprouty homolog 3; Spry-3 (SPRY3)

Function

• may function as an antagonist of fibroblast growth factor (FGF) pathways
• may negatively modulate respiratory organogenesis

Structure

• the Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
• belongs to the sprouty family
• contains 1 SPR (sprouty) domain

Compartment

• cytoplasm, peripheral membrane
• found in the cytoplasm in unstimulated cells
• translocated to membrane ruffles in cells stimulated with epidermal growth factor (EGF)

Expression

• widely expressed;
• expressed in fetal tissues
• induced by FGF signaling

Genetics

• the gene encoding this protein is located in the pseudoautosomal region 2 (PAR2) of the X chromosome & Y chromosome

More general terms

• sprouty homolog
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10251
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10251
• OMIM: https://mirror.omim.org/entry/300531
• UniProt: http://www.uniprot.org/uniprot/O43610.html