protein sprouty homolog 1; Spry-1 (SPRY1)

Function

• may function as an antagonist of fibroblast growth factor (FGF) pathways
• may negatively modulate respiratory organogenesis

Structure

• the Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
• belongs to the sprouty family
• contains 1 SPR (sprouty) domain

Compartment

• cytoplasm, peripheral membrane
• found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with epidermal growth factor (EGF)

Expression

• induced by FGF signaling

More general terms

• sprouty homolog
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10252
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10252
• OMIM: https://mirror.omim.org/entry/602465
• UniProt: http://www.uniprot.org/uniprot/O43609.html