alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; N-acetylglucosaminyltransferase IVc; GnT-IVc; GlcNAc-T IVc; N-acetylglucosaminyltransferase IV homolog; hGnT-IV-H (MGAT4C)

Function

• glycosyltransferase, protein Asn glycosylation
• role in transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans
• catalyzes formation of GlcNAcbeta1-4 branch on GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans
• essential for the production of tri- & tetra-antennary N-linked sugar chains
• does not catalyze transfer of GlcNAc to Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity)

Cofactor: divalent metal cations

Structure

belongs to the glycosyltransferase 54 family

Compartment

Golgi

Expression

• expressed in heart, adrenal gland, testis, liver, brain. fetal brain
• not expressed in pancreas

More general terms

• UDP-N-acetylglucosamine:alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminultransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25834
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25834
• OMIM: https://mirror.omim.org/entry/607385
• UniProt: http://www.uniprot.org/uniprot/Q9UBM8.html