beta-secretase 2, beta-site APP-cleaving enzyme 2 (BACE 2) or Asp1 protein

Function

• broad endopeptidase specificity
• interacts ith RTN3 & RTN4

Structure

belongs to the peptidase A1 family

Compartment

membrane

Pathology

• cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of APP

More general terms

• APP beta-secretase or beta-site APP-cleaving enzyme (BACE)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y5Z0.html
• OMIM: https://mirror.omim.org/entry/605668
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25825