voltage-dependent L-type Ca+2 channel beta-3; CAB3; Ca+2 channel voltage-dependent subunit beta 3 (CACNB3, CACNLB3)
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Function
- beta subunit of voltage-dependent Ca+2 channels, L-type Ca+2 channel subunit (1 of 4 subunits: alpha-1, alpha-2, beta & gamma)
- contributes to the function of the Ca+2 channel by increasing peak Ca+2 current, shifting the voltage dependencies of activation & inactivation, modulating G protein inhibition & controlling the alpha-1 subunit membrane targeting
- interacts with CACNA2D4
Structure
- belongs to the Ca+2 channel beta subunit family
- contains 1 SH3 domain
Alternative splicing
named isoforms=2
Expression
- expressed mostly in brain, smooth muscle & ovary[3]
- expressed predominantly in brain[2]
More general terms
Additional terms
References
- ↑ Witcher DR, De Waard M, Sakamoto J, Franzini-Armstrong C, Pragnell M, Kahl SD, Campbell KP. Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain. Science. 1993 Jul 23;261(5120):486-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8392754
- ↑ 2.0 2.1 Castellano A, Wei X, Birnbaumer L, Perez-Reyes E. Cloning and expression of a third calcium channel beta subunit. J Biol Chem. 1993 Feb 15;268(5):3450-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7679112
- ↑ 3.0 3.1 UniProt http://www.uniprot.org/uniprot/P54284.html