mitochondrial import receptor subunit TOM20 homolog; mitochondrial 20 kD outer membrane protein; outer mitochondrial membrane receptor Tom20 (TOMM20, KIAA0016)

Function

• import of protein precursors into the mitochondria
• forms part of mitochondrial receptor complex
• together with TOMM22 functions as transit peptide receptor at surface of mitochondrial outer membrane
• facilitates movement of preproteins into the TOMM40 translocation pore
• forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex)
• interacts with TOMM22
• interacts with APEX1
• ubiquitinated by PARK2 during mitophagy, leading to its degradation & enhancement of mitophagy
• deubiquitinated by USP30

Structure

• belongs to the Tom20 family

Compartment

mitochondrial outer membrane

More general terms

• mitochondrial membrane protein

Component of

• mitochondrial receptor complex; preprotein translocase complex; TOM complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9804
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9804
• OMIM: https://mirror.omim.org/entry/601848
• UniProt: http://www.uniprot.org/uniprot/Q15388.html