mitochondrial import receptor subunit TOM22 homolog; translocase of outer membrane 22 kD subunit homolog (TOMM22, TOM22, hTom22, 1C9-2)

Function

• import of protein precursors into the mitochondria
• forms part of mitochondrial receptor complex
• together with TOMM20 functions as transit peptide receptor at surface of mitochondrial outer membrane
• facilitates movement of preproteins into the TOMM40 translocation pore
• component of the TOM complex
• interacts with TOMM20
• interacts with PPP2R2B (putative)

Structure

• requires the transmembrane domain (TMD), a short segment (the import sequence) in the cytoplasmic domain localizing separately from the TMD & the C-tail signal in the C-terminal domain for efficient targeting & integration into the TOM complex (putative)
• the N-terminal domain (residues 1-62) is important for binding to the unfolded mature imported proteins
• residues (49-71) of the cytoplasmic domain interacts with TOMM20
• the C-terminal segment (residues 63-82) binds presequence of preproteins
• belongs to the Tom22 family

Compartment

• mitochondrial outer membrane
• single-pass membrane protein

Expression

ubiquitous

More general terms

• mitochondrial membrane protein
• phosphoprotein

Component of

• mitochondrial receptor complex; preprotein translocase complex; TOM complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56993
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56993
• OMIM: https://mirror.omim.org/entry/607046
• UniProt: http://www.uniprot.org/uniprot/Q9NS69.html