hexokinase-2 (hexokinase type II, HK II, muscle form hexokinase, HK2)

Function

• carbohydrate metabolism, hexose metabolism
• allosteric enzyme inhibited by its product Glc-6-P

ATP + D-hexose <--> ADP + D-hexose 6-phosphate

Structure

• monomer
• N- & C-terminal halves show extensive sequence similarity to each other
• catalytic activity is associated with the C-terminus
• regulatory function is associated with the N-terminus hydrophobic N-terminal sequence may be involved in membrane binding
• belongs to the hexokinase family

Compartment

mitochondrial outer membrane

Expression

• predominant hexokinase isozyme expressed in insulin-responsive tissues, including skeletal muscle

Polymorphism

• genetic variations of HK2 do not contribute to the NIDDM

Notes

• in vertebrates there are 4 major glucose-phosphorylating isoenzymes, designated hexokinase 1, 2, 3 & 4 (glucokinase)

More general terms

• hexokinase
• mitochondrial membrane protein

Database

• OMIM: https://mirror.omim.org/entry/601125
• UniProt: http://www.uniprot.org/uniprot/P52789.html