glucokinase (GCK, hexokinase-D, hexokinase-4)

Function

• participates in glucose transport into cells
• phosphorylation of glucose by glucokinase after internalization drives transport of glucose by making the resultant glucose-6-phosphate irreversibly trapped inside the cell

Expression

• expressed only in liver & pancreatic islets

Pathology

• mutations in the gene for glucokinase are involved in 60% of cases of mature onset diabetes of the young (MODY).

More general terms

• hexokinase
• glycolytic enzyme

More specific terms

• ADP-dependent glucokinase; ADP-GK; ADPGK; RbBP-35 (ADPGK)

Additional terms

• youth-onset type 2 diabetes; mature onset diabetes of the young (MODY)

Database

• OMIM: https://mirror.omim.org/entry/600842
• OMIM: https://mirror.omim.org/entry/138079