ADP-dependent glucokinase; ADP-GK; ADPGK; RbBP-35 (ADPGK)

Function

• catalyzes phosphorylation of D-glucose to D-glucose-6-phosphate using ADP as the phosphate donor
• GDP & CDP can replace ADP, but with reduced efficiency (putative)
• carbohydrate degradation; glycolysis

ADP + D-glucose = AMP + D-glucose-6-phosphate

Cofactor: binds 1 Mg+2 per subunit (putative)

Structure

• monomer (putative)
• belongs to the ADP-dependent glucokinase family
• contains 1 ADPK (ADP-dependent kinase) domain

Compartment

secreted (putative)

Alternative splicing

named isoforms=6

More general terms

• glucokinase (GCK, hexokinase-D, hexokinase-4)
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83440
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83440
• OMIM: https://mirror.omim.org/entry/611861
• UniProt: http://www.uniprot.org/uniprot/Q9BRR6.html