natural cytotoxicity triggering receptor 2; lymphocyte antigen 95 homolog; NK cell-activating receptor; natural killer cell p44-related protein; NK-p44; NKp44; CD336 (NCR2, LY95)

Function

• cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis
• interacts with TYROBP/DAP12

Structure

• belongs to the natural cytotoxicity receptor (NCR) family
• contains 1 Ig-like (immunoglobulin-like) domain

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=3

Expression

• selectively expressed by activated NK cells & by in vitro cultured (i.e. activated) TCRg/d lymphoid cells

More general terms

• natural cytotoxicity triggering receptor
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9436
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9436
• OMIM: https://mirror.omim.org/entry/604531
• UniProt: http://www.uniprot.org/uniprot/O95944.html