natural cytotoxicity triggering receptor 1; lymphocyte antigen 94 homolog; NK cell-activating receptor; natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335 (NCR1, LY94)

Function

• cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis
• interacts with CD247 & FCER1G

Structure

• N-glycosylated
• O-glycosylated
• belongs to the natural cytotoxicity receptor (NCR) family
• contains 2 Ig-like (immunoglobulin-like) domains

Compartment

• cell membrane; single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=6

Expression

• selectively expressed by both resting & activated NK cells

More general terms

• natural cytotoxicity triggering receptor
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9437
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9437
• OMIM: https://mirror.omim.org/entry/604530
• UniProt: http://www.uniprot.org/uniprot/O76036.html