protocadherin-11 Y-linked; protocadherin-11; protocadherin-22; protocadherin on the Y chromosome; PCDH-Y; protocadherin prostate cancer; protocadherin-PC (PCDH11Y, PCDH11, PCDH22, PCDHY)

Function

• Ca+2-dependent cell-adhesion protein (putative)
• interacts with CTNNB

Structure

contains 7 cadherin domains

Compartment

• cell membrane
• single-pass type 1 membrane protein (putative)

Alternative splicing

• named isoforms=4
• comment=additional isoforms seem to exist

Expression

• expressed in fetal brain & brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus & corpus callosum)

expressed at low level in testis

• expressed in apoptosis-resistant cells

Pathology

• chromosomal translocation t(Y;3)(p11;p12) involving PCDH11Y with ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects

More general terms

• protocadherin (PCDH)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83259
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83259
• OMIM: https://mirror.omim.org/entry/400022
• UniProt: http://www.uniprot.org/uniprot/Q9BZA8.html