roundabout homolog 2 (ROBO2, KIAA1568, SAX3)

Function

• receptor for SLIT2 & probably SLIT1
• molecular guidance in cellular migration, including axonal navigation at ventral midline of neural tube & projection of axons to different regions during neuronal development

Structure

• belongs to the immunoglobulin superfamily, ROBO family
• contains 3 fibronectin F3 modules
• contains 5 Ig-like C2-type domains (immunoglobulin-like)

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• cell surface receptor
• immunoglobulin superfamily protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/602431
• UniProt: http://www.uniprot.org/uniprot/Q9HCK4.html