taste receptor, type 2, member 8 (T2R8, taste receptor family B member 5, TRB5, TAS2R8)

Function

• perception of bitterness
• gustducin-linked
• senses chemical composition of GI content (putative)
• stimulates alpha gustducin (putative)
• PLC-beta-2
• gating of TRPM5

Structure

belongs to the G-protein coupled receptor T2R family

Compartment

membrane

Expression

• expressed in subsets of taste receptor cells of the tongue & palate epithelium, exclusively in gustducin-positive cells.

More general terms

• taste receptor, type 2

Database

• OMIM: https://mirror.omim.org/entry/604794
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5083
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=50836
• UniProt: http://www.uniprot.org/uniprot/Q9NYW2.html