fibulin-7 (FBLN7 TM14)

Function

• adhesion molecule
• interacts with extracellular matrix molecules in developing teeth
• role in differentiation & maintenance of odontoblasts
• role in dentin formation (putative)
• interacts with heparin, FBLN1, FN1 & DSPP
• preferentially binds dental mesenchyme cells & odontoblasts but not dental epithelial cells or nondental cells
• binding requires a heparan sulfate-containing receptor on the cell surface as well as an integrin (putative)

Structure

• N-glycosylated (putative)
• belongs to the fibulin family
• contains 2 EGF-like domains
• contains 1 Sushi (CCP/SCR) domain

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Alternative splicing

named isoforms=4

More general terms

• fibulin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1298
• UniProt: http://www.uniprot.org/uniprot/Q53RD9.html