dentin sialophosphoprotein [Contains: Dentin phosphoprotein (Dentin phosphophoryn, DPP); Dentin sialoprotein (DSP)] (DSPP)

Function

• role in dentinogenesis
• binds Ca+2, facilitates initial mineralization of dentin matrix collagen, regulates size & shape of crystals

Compartment

secreted

Expression

• expressed in teeth
• synthesized by odontoblast
• transiently expressed by pre-ameloblasts

Pathology

• defects in DSPP are the cause of dentinogenesis imperfecta 1

More general terms

• sialoglycoprotein
• phosphoprotein
• secreted protein
• Ca+2 binding protein

Database

• OMIM: https://mirror.omim.org/entry/125485
• OMIM: https://mirror.omim.org/entry/125490
• OMIM: https://mirror.omim.org/entry/605594
• UniProt: http://www.uniprot.org/uniprot/Q9NZW4.html