fibulin-2; FIBL-2 (FBLN2)

Function

• binding to fibronectin & some other ligands is Ca+2 dependent
  • interacts with LAMA2

Structure

• glycosylated with core 1 glycan or possibly core 8 glycans
• unclear if O-glycosylation is on Thr-347 or Ser-348
• homotrimer; disulfide-linked.
• belongs to the fibulin family
• contains 3 anaphylatoxin-like domains
• contains 11 EGF-like domains

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

named isoforms=2

Expression

• component of both basement membranes & other connective tissues
• expressed in heart, placenta & ovary
• widely expressed during embryonic development
• primarily detected within the neuropithelium, spinal ganglia & peripheral nerves

More general terms

• fibulin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2199
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2199
• OMIM: https://mirror.omim.org/entry/135821
• UniProt: http://www.uniprot.org/uniprot/P98095.html