sialic acid-binding Ig-like lectin 10; siglec-10; siglec-like protein 2 (SIGLEC10, SLG2, UNQ477/PRO940)

Function

• putative adhesion molecule that mediates sialic-acid dependent binding to cells
• preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid
• the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface
• in the immune response, may act as an inhibitory receptor upon ligand induced Tyr phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules
• phosphorylation of Tyr-667 is involved in binding to PTPN6
• interacts with PTPN6/SHP-1 upon phosphorylation

Structure

• contains 1 ITIM motif
• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 3 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• isoforms 1, 2, 3, & 4: cell membrane; single-pass type 1 membrane protein
• isoform 5: secreted

Alternative splicing

named isoforms=6

Expression

• expressed by peripheral blood leukocytes (eosinophils, monocytes & a natural killer cell subpopulation)
• isoform 5 is found to be the most abundant isoform
• found in lymph node, lung, ovary & appendix
• isoform 1 is found at high levels & isoform 2 at lower levels in bone marrow, spleen & spinal cord
• isoform 2 is also found in brain
• isoform 4 is specifically found in natural killer cells

More general terms

• sialic acid-binding immunoglobulin-like lectin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=89790
• OMIM: https://mirror.omim.org/entry/606091
• UniProt: http://www.uniprot.org/uniprot/Q96LC7.html