sialic acid-binding Ig-like lectin 9; siglec-9; protein FOAP-9 (SIGLEC9)

Function

• putative adhesion molecule that mediates sialic-acid dependent binding to cells
• preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid
• the sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface

Structure

• contains 1 ITIM motif
• belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
• contains 2 Ig-like C2-type domains (immunoglobulin-like)
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• expressed by peripheral blood leukocytes (neutrophils & monocytes but not eosinophils)
• found in liver, fetal liver, bone marrow, placenta, spleen & in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine & spinal cord

More general terms

• sialic acid-binding immunoglobulin-like lectin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27180
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27180
• OMIM: https://mirror.omim.org/entry/605640
• UniProt: http://www.uniprot.org/uniprot/Q9Y336.html