desmocollin-2; desmosomal glycoprotein II & III; desmocollin-3 (DSC2, CDHF2, DSC3)

Function

• component of intercellular desmosome junctions
• involved in the interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion
• may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms

Structure

• Ca+2 may be bound by the cadherin-like repeats
• contains 5 cadherin domains

Compartment

• cell membrane; single-pass type 1 membrane protein
• cell junction, desmosome

Alternative splicing

named isoforms=2; 2A (DGII); 2B (DGIII)

Expression

expressed in epithelia, myocardium & lymph nodes

Pathology

• defects in DSC2 are the cause of familial arrhythmogenic right ventricular dysplasia 11

Notes

formerly desmocollin 3

More general terms

• desmocollin
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q02487.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1824
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1824
• OMIM: https://mirror.omim.org/entry/125645
• OMIM: https://mirror.omim.org/entry/610476