desmocollin-3; desmocollin-4; HT-CP (DSC3, CDHF3, DSC4)

Function

• component of intercellular desmosome junctions
• involved in the interaction of plaque proteins & intermediate filaments
• mediating cell-cell adhesion
• may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms

Structure

• Ca+2 may be bound by the cadherin-like repeats
• contains 5 cadherin domains

Compartment

• cell membrane; single-pass type 1 membrane protein
• cell junction, desmosome

Alternative splicing

named isoforms=2; 3A, 3B

Expression

epidermis, buccal mucosa, esophagus & cervix

Notes

formerly desmocollin 4

More general terms

• desmocollin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1825
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1825
• OMIM: https://mirror.omim.org/entry/600271
• UniProt: http://www.uniprot.org/uniprot/Q14574.html