desmocollin-1; desmosomal glycoprotein 2/3; DG2/DG3 (DSC1 CDHF1)

Function

• component of intercellular desmosome junctions
• involved in the interaction of plaque proteins & intermediate filaments
• mediating cell-cell adhesion
• may contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms
• linked to the keratinization of epithelial tissues

Structure

• Ca+2 may be bound by the cadherin-like repeats
• contains 5 cadherin domains

Compartment

• cell membrane; single-pass type 1 membrane protein
• cell junction, desmosome

Alternative splicing

named isoforms=2; 1A (DG2); 1B (DG3)

Expression

• strongly expressed in epidermis, less in lymph node & tongue

More general terms

• desmocollin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1823
• OMIM: https://mirror.omim.org/entry/125643
• UniProt: http://www.uniprot.org/uniprot/Q08554.html