desmoglein-2; HDGC (DSG2, CDHF5)

Function

• component of intercellular desmosome junctions
• involved in the interaction of plaque proteins & intermediate filaments mediating cell-cell adhesion

Structure

• Ca+2 may be bound by the cadherin-like repeats
• contains 4 cadherin domains

Compartment

• cell membrane; single-pass type 1 membrane protein
• cell junction, desmosome

Expression

all tissues tested including carcinomas

Pathology

• defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia 10

More general terms

• desmoglein (desmosomal glycoprotein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1829
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1829
• OMIM: https://mirror.omim.org/entry/125671
• OMIM: https://mirror.omim.org/entry/610193
• UniProt: http://www.uniprot.org/uniprot/Q14126.html