chorionic gonadotropin [cG]-beta chain (CG-beta, beta-hcG, CGB)

Function

• stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Structure

• heterodimer of a common alpha chain (glycoprotein hormone alpha) & a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin & gonadotropin
• belongs to the glycoprotein hormones subunit beta family

Compartment

secreted

Expression

• placenta
• made by the first trimester placenta Pharmaceutical:
• available under the names Novarel (ferring) & Profasi (serono)

Laboratory

• beta-chorionic gonadotropin in specimen
  • beta-chorionic gonadotropin in body fluid
    • beta-chorionic gonadotropin in amniotic fluid
    • beta-chorionic gonadotropin in CSF
    • beta-chorionic gonadotropin in peritoneal fluid
    • beta-chorionic gonadotropin in pleural fluid beta-chorionic gonadotropin in serum/plasma
• choriogonadotropin.beta subunit free in body fluid
  • choriogonadotropin.beta subunit free in amniotic fluid
  • choriogonadotropin.beta subunit free in CSF
  • choriogonadotropin.beta subunit free in serum/plasma

More general terms

• glycoprotein hormone-beta chain

More specific terms

• choriogonadotropin subunit beta 3 (CGB3, CGB5, CGB8)
• choriogonadotropin subunit beta 7 (CGB7)
• ferring (beta-hcG, Novarel, Profasi, serono)

Additional terms

• beta-chorionic gonadotropin (hCG) in serum/plasma

Component of

• chorionic gonadotropin; choriogonadotropin (APL, hCG)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1082
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9365
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9411
• OMIM: https://mirror.omim.org/entry/118860
• OMIM: https://mirror.omim.org/entry/608825
• OMIM: https://mirror.omim.org/entry/608826
• OMIM: https://mirror.omim.org/entry/608827
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1082